Improving weak-signal identification via predetection background suppression by a pixel-level, surface-wave enabled dark-field aperture

We report the successful implementation of a surface-wave enabled dark-field aperture (SWEDA) directly on a complementary metal-oxide semiconductor sensor pixel (2.2μm). This SWEDA pixel allows predetection cancellation of a uniform coherent background. We show that the signal-to-noise ratio (SNR) of the SWEDA pixel is better than that of a single undressed pixel over a significant range of signal-to-background ratio (SBR). For a small SBR value (SBR=0.001, background intensity=3.96W/m^2, integration time=5ms), we further demonstrate that a SWEDA pixel can detect a weak localized signal buried in a high background, while conventional postdetection background subtraction cannot (improved SNR=2.2 versus SNR=0.26)

Electromagnetic equivalent model for phase conjugate mirror based on the utilization of left-handed material

An electromagnetic equivalent model for the phase conjugate mirror (PCM) is proposed in this paper. The model is based on the unique property of the isotropic left-handed material (LHM) - the ability of LHM to reverse the phase factors of propagative waves. We show that a PCM interface can be substituted with a LHM-RHM (right-handed material) interface and associated image sources and objects in the LHM. This equivalent model is fully equivalent in the treatment of propagative wave components. However, we note that the presence of evanescent wave components can lead to undesirably surface resonance at the LHM-RHM interface. This artefact can be kept well bounded by introducing a small refractive index mismatch between the LHM and RHM. We demonstrate the usefulness of this model by modelling several representative scenarios of light patterns interacting with a PCM. The simulations were performed by applying the equivalent model to a commercial finite element method (FEM) software. This equivalent model also points to the intriguing possibility of realizing some unique LHM based systems in the optical domain by substituting a PCM in place of a LHM-RHM interface

Microscopy refocusing and dark-field imaging by using a simple LED array

The condenser is one of the main components in most transmitted light compound microscopes. In this Letter, we show that such a condenser can be replaced by a programmable LED array to achieve greater imaging flexibility and functionality. Without mechanically scanning the sample or changing the microscope setup, the proposed approach can be used for dark-field imaging, bright-field imaging, microscopy sectioning, and digital refocusing. Images of a starfish embryo were acquired by using such an approach for demonstration

A phase conjugate mirror inspired approach for building cloaking structures with left-handed materials

In this paper, we propose and examine a new cloaking method, which was inspired by the close correspondence between a phase conjugate mirror and the interface between a pair of matched right-handed material (RHM) and left-handed material (LHM) media. Using this method, we show that a symmetric conducting shell embedded in the interface junction of an isotropic RHM layer and an isotropic negative index or LHM layer can serve as a limited cloaking structure. The proposed structure presents an anomalously small scattering cross-section to an incident propagating electromagnetic (EM) field. The interior of the shell can be used to shield small objects from interrogation. We report the results of 2D finite-element-method (FEM) simulations that were performed to verify the principle, and discuss the limitations of the proposed structure

Focal plane tuning in wide-field-of-view microscope with Talbot pattern illumination

We have developed a focal plane tuning technique for use in focus-grid-based wide-field-of-view microscopy (WFM). In WFM, the incidence of a collimated beam on a mask with a two-dimensional grid of aperture produced the Talbot images of the aperture grid. The Talbot pattern functioned as a focus grid and was used to illuminate the sample. By scanning the sample across the focus grid and collecting the transmission, we can generate a microscopy image of the sample. By tuning the wavelength of the laser, we can tune the focal plane of the WFM and acquire images of different depth into the sample. Images of a green algae microscope slide were acquired at different focal planes for demonstration

Optical imaging techniques in microfluidics and their applications

Microfluidic devices have undergone rapid development in recent years and provide a lab-on-a-chip solution for many biomedical and chemical applications. Optical imaging techniques are essential in microfluidics for observing and extracting information from biological or chemical samples. Traditionally, imaging in microfluidics is achieved by bench-top conventional microscopes or other bulky imaging systems. More recently, many novel compact microscopic techniques have been developed to provide a low-cost and portable solution. In this review, we provide an overview of optical imaging techniques used in microfluidics followed with their applications. We first discuss bulky imaging systems including microscopes and interferometer-based techniques, then we focus on compact imaging systems that can be better integrated with microfluidic devices, including digital in-line holography and scanning-based imaging techniques. The applications in biomedicine or chemistry are also discussed along with the specific imaging techniques

Pixel level optical-transfer-function design based on the surface-wave-interferometry aperture

The design of optical transfer function (OTF) is of significant importance for optical information processing in various imaging and vision systems. Typically, OTF design relies on sophisticated bulk optical arrangement in the light path of the optical systems. In this letter, we demonstrate a surface-wave-interferometry aperture (SWIA) that can be directly incorporated onto optical sensors to accomplish OTF design on the pixel level. The whole aperture design is based on the bull’s eye structure. It composes of a central hole (diameter of 300 nm) and periodic groove (period of 560 nm) on a 340 nm thick gold layer. We show, with both simulation and experiment, that different types of optical transfer functions (notch, highpass and lowpass filter) can be achieved by manipulating the interference between the direct transmission of the central hole and the surface wave (SW) component induced from the periodic groove. Pixel level OTF design provides a low-cost, ultra robust, highly compact method for numerous applications such as optofluidic microscopy, wavefront detection, darkfield imaging, and computational photography